Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells

Abstract Background As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen. Methods Co-i...

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Detalhes bibliográficos

Principais autores:	Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi, Jianxiang Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-11-01
coleção:	BMC Cancer
Assuntos:	iASPP Sertad1 P53 Apoptosis Leukemic cell
Acesso em linha:	http://link.springer.com/article/10.1186/s12885-017-3787-2
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