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Effective Gene Expression Prediction and Optimization from Protein Sequences

Abstract High soluble protein expression in heterologous hosts is crucial for various research and applications. Despite considerable research on the impact of codon usage on expression levels, the relationship between protein sequence and expression is often overlooked. In this study, a novel conne...

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Autori principali: Tuoyu Liu, Yiyang Zhang, Yanjun Li, Guoshun Xu, Han Gao, Pengtao Wang, Tao Tu, Huiying Luo, Ningfeng Wu, Bin Yao, Bo Liu, Feifei Guan, Huoqing Huang, Jian Tian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2025-02-01
Serie:Advanced Science
Soggetti:
amino acid expression index
mutant generation
predicting protein expression
soluble expression
transfer learning
Accesso online:https://doi.org/10.1002/advs.202407664
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