Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors

Background and purpose: Histone deacetylation is one of the essential cellular pathways in the growth and spread of cancer, so the design of histone deacetylase (HDAC) inhibitors as anticancer agents is of great importance in pharmaceutical chemistry. Here, a series of indole acylhydrazone derivativ...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Niloofar Naghi-Ganji, Lotfollah Saghaei, Farial Tavakoli, Vajihe Azimian, Mina Mirian, Hajar Sirous, Mahboubeh Rostami
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wolters Kluwer Medknow Publications 2022-01-01
Serier:	Research in Pharmaceutical Sciences
Fag:	acylhydrazone; cytotoxicity; hdac inhibitor; indole; molecular docking 4-pyridone
Online adgang:	http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=5;spage=572;epage=584;aulast=Naghi-Ganji
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!