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Are minor alleles more likely to be risk alleles?

Abstract Background Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high...

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Principais autores: Takashi Kido, Weronika Sikora-Wohlfeld, Minae Kawashima, Shinichi Kikuchi, Naoyuki Kamatani, Anil Patwardhan, Richard Chen, Marina Sirota, Keiichi Kodama, Dexter Hadley, Atul J. Butte
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-01-01
coleção:BMC Medical Genomics
Assuntos:
GWASs
Complex diseases
Minor alleles
Risk alleles
Negative natural selection
Acesso em linha:http://link.springer.com/article/10.1186/s12920-018-0322-5
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