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Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at angiotensin AR1 receptors, suggesting the receptor may have evolved to accommodate naturally occurring angiotensin ‘antipeptides’. Screening of the hu...

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Principais autores: Graham J. Moore, Harry Ridgway, Konstantinos Kelaidonis, Christos T. Chasapis, Irene Ligielli, Thomas Mavromoustakos, Joanna Bojarska, John M. Matsoukas
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-07-01
Serier:Molecules
Fag:
COVID-19
angiotensin II
angiotensin II receptors
biased agonism
molecular dynamics (MD)
angiotensin II receptor blockers (ARBS)
Online adgang:https://www.mdpi.com/1420-3049/27/15/4854
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