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TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche

Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key niche factors and myelofibrosis. Here, we explored the contribution of TGF-β to these alterations by abrogating TGF-β signaling in bone marrow...

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Principais autores: Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. Link
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2022-06-01
Serier:The Journal of Clinical Investigation
Fag:
Hematology
Oncology
Online adgang:https://doi.org/10.1172/JCI154092
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