Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma

Abstract Background Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β2-adrenergic receptor (AR) agonists (LAB...

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Autors principals:	Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K. Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2017-11-01
Col·lecció:	Respiratory Research
Matèries:	Fibrocytes Severe asthma β2-adrenergic receptor Corticosteroids cAMP
Accés en línia:	http://link.springer.com/article/10.1186/s12931-017-0678-7
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