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The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching

Summary: Robust alternative end joining (A-EJ) in classical non-homologous end joining (c-NHEJ)-deficient murine cells features double-strand break (DSB) end resection and microhomology (MH) usage and promotes chromosomal translocation. The activities responsible for removing 3′ single-strand overha...

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Principais autores: Wanyu Bai, Guangchao Zhu, Jiejie Xu, Pingyue Chen, Feilong Meng, Hongman Xue, Chun Chen, Junchao Dong
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-09-01
Serier:Cell Reports
Fag:
DSB repair
alternative end joining
class switch recombination
chromosomal translocation
DNA ligase 4
53BP1
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124721012109
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