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Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression

Abstract Background Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DN...

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Principais autores: Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Ryan
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2018-09-01
סדרה:BMC Psychiatry
נושאים:
Depression
DNA methylation
Epigenetics
Genetic variation
Serotonin transporter
גישה מקוונת:http://link.springer.com/article/10.1186/s12888-018-1850-4
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