Nanozyme-driven self-assembled rhein gels for osteoarthritis therapy: Alleviating chondrocyte inflammation by reprogramming macrophages

Osteoarthritis (OA), the fourth leading cause of global disability, is marked by progressive cartilage loss, synovial inflammation, and dysregulated bone remodeling. Current therapeutic strategies are hindered by systemic adverse effects and insufficient intra-articular drug bioavailability, undersc...

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Detalhes bibliográficos

Principais autores:	Jian Jiang, Chao Song, Xuefeng Hou, Kangjie Xu, Zhongkai Ji, Lei Fan, Juqun Xi, Ailang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-10-01
coleção:	Materials Today Bio
Assuntos:	Osteoarthritis Synovial macrophages Gel Enzyme-mimetic activity Anti-inflammatory
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2590006425007318
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