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Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH

Summary: Although recent evidence suggests the involvement of iron accumulation in the pathogenesis of nonalcoholic steatohepatitis (NASH), the underlying mechanisms remain poorly understood. Previously, we reported a unique histological structure termed “crown-like structure (CLS),” where liver-res...

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Principais autores: Yohei Kanamori, Miyako Tanaka, Michiko Itoh, Kozue Ochi, Ayaka Ito, Isao Hidaka, Isao Sakaida, Yoshihiro Ogawa, Takayoshi Suganami
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021-02-01
Series:iScience
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2589004220312293
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