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IMPACTS OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (TPA) ON NEURONAL SURVIVAL

Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins and receptors. In the last years, great interest has been given to the clinical relevance of targeting tPA in different diseases...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Arnaud eChevilley, Flavie eLesept, Sophie eLenoir, Carine eAli, Jérôme eParcq, Denis eVivien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015-10-01
Schriftenreihe:Frontiers in Cellular Neuroscience
Schlagworte:
Apoptosis
excitotoxicity
NMDA receptors
tissue-type plasminogen activator
diiferential effects
Online-Zugang:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00415/full
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