Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep

Abstract Background Therapeutic hypothermia significantly improves outcomes after moderate–severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. Although hypothermia is consistently associated with reduced microgliosis, it is still unclear whether it normalizes microglial morp...

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Detalhes bibliográficos

Principais autores:	Kelly Q. Zhou, Laura Bennet, Guido Wassink, Alice McDouall, Maurice A. Curtis, Blake Highet, Taylor J. Stevenson, Alistair J. Gunn, Joanne O. Davidson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-06-01
coleção:	Journal of Neuroinflammation
Assuntos:	Hypoxia-ischemia Therapeutic hypothermia Neuroinflammation Microglial phenotype Gitter cells Electroencephalogram
Acesso em linha:	https://doi.org/10.1186/s12974-022-02499-7
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