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Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes

We have found that the overexpression of the centriolar protein SAS-6 causes an increase in cell invasion through the activation of the YAP/TAZ pathway. Centriole and/or cilium defects are characteristic of cancer cells and have been linked to cancer cell invasion. However, the mechanistic bases of...

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Principais autores: Eleanor Hargreaves, Rebecca Collinson, Andrew D Jenks, Adina Staszewski, Athanasios Tsalikis, Raquel Bodoque, Mar Arias-Garcia, Yasmin Abdi, Abdulaziz Al-Malki, Yinyin Yuan, Rachael Natrajan, Syed Haider, Thomas Iskratsch, Won-Jing Wang, Susana Godinho, Nicolaos J Palaskas, Fernando Calvo, Igor Vivanco, Tobias Zech, Barbara E Tanos
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2025-10-01
coleção:Life Science Alliance
Acesso em linha:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202402820
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