Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

Ca2+ and Vm transitions occurring throughout action potential (AP) cycles in sinoatrial nodal (SAN) cells are cues that (1) not only regulate activation states of molecules operating within criticality (Ca2+ domain) and limit-cycle (Vm domain) mechanisms of a coupled-clock system that underlies SAN...

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Hlavní autoři:	Dongmei Yang, Christopher H. Morrell, Alexey E. Lyashkov, Syevda Tagirova Sirenko, Ihor Zahanich, Yael Yaniv, Tatiana M. Vinogradova, Bruce D. Ziman, Victor A. Maltsev, Edward G. Lakatta
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-09-01
Edice:	Frontiers in Physiology
Témata:	single sinoatrial nodal pacemaker cells local diastolic Ca2+ releases diastolic depolarization autonomic receptor stimulation self-similarity of Ca2+ and membrane potential during action potentials action potential
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphys.2021.612770/full
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