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Expression and Activation of BKCa Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function

Aims: Activation and expression of large conductance calcium and voltage-activated potassium channel (BKCa) by pharmacological agents have been implicated in cardioprotection from ischemia-reperfusion (IR) injury possibly by regulating mitochondrial function. Given the non-specific effects of pharma...

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Principais autores: Sumanta Kumar Goswami, Devasena Ponnalagu, Ahmed T. Hussain, Kajol Shah, Priyanka Karekar, Shubha Gururaja Rao, Andrea L. Meredith, Mahmood Khan, Harpreet Singh
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-01-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
cardiac mitochondria
BKCa channels
reactive oxygen species
ischemia-reperfusion injury
myocardial infarction
ischemic preconditioning
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcvm.2018.00194/full
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