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Systemic sclerosis-associated pulmonary arterial hypertension and pulmonary fibrosis: exploring biomarker discriminators with advanced omics in a Caucasian cohort

IntroductionSystemic sclerosis (Scleroderma; SSc) is associated with high morbidity and mortality, particularly in patients with pulmonary arterial hypertension (SSc-PAH) and pulmonary fibrosis (SSc-PF). Effective risk stratification and treatment of SSc remains a significant challenge. This proof-o...

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Principais autores: Nada Mohamed-Ali, Vanessa Acquaah, Maneera Al-Jaber, Rikesh Bhatt, Ibrahim Al-Mohannadi, Konduru Seetharama Sastry, Alka Beotra, Daniel Knight, Christopher Denton, Voon Ong, Maryam Ali Al-Nesf, David Abraham, Mohammed Al-Maadheed, Markella Ponticos, Vidya Mohamed-Ali
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2026-02-01
Series:Frontiers in Immunology
Assuntos:
biomarkers
metabolomics
proteomics
pulmonary fibrosis
pulmonary hypertension
systemic sclerosis
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1755076/full
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