Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs

Annually, swine influenza A virus (SwIAV) causes severe economic loss to swine industry. Currently used inactivated SwIAV vaccines administered by intramuscular injection provide homologous protection, but limited heterologous protection against constantly evolving field viruses, attributable to the...

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Główni autorzy:	Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T. Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J. Renukaradhya
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2018-05-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	swine influenza virus chitosan nanoparticles mucosal immune response intranasal vaccination pigs
Dostęp online:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00934/full
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