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Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16

Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, and the evasion of host immune responses. Currently, debulking surgery and plati...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Gunnar Kvalheim, Kristina Lindemann, Ben Davidson, Line Bjorge, Else Marit Inderberg, Sébastien Wälchli, Emmet McCormack, Katrin Kleinmanns, David J Warren, Erik Rokkones, Martine Lode, Nicholas P Casey, Christopher Forcados, Pascal F Gelebart, Sandy Joaquina, Emmanuelle Benard, Fatemeh Kaveh, Benjamin Caulier, Christiane Helgestad Gjerde, Elvira García de Jalón, Marit Renee Myhre
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2024-04-01
Schriftenreihe:Journal for ImmunoTherapy of Cancer
Online-Zugang:https://jitc.bmj.com/content/12/4/e008179.full
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