Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods

Abstract Selenoproteins incorporate the rare selenium-containing amino acid selenocysteine (Sec) and play crucial roles for redox homeostasis, stress response, and hormone regulation. Sec is inserted by co-translational recoding of the UGA codon, normally a stop. As a consequence, selenoproteins are...

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Bibliografische Detailangaben

Hauptverfasser:	Max Ticó, Jesus Lozano-Fernandez, Marco Mariotti
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-03-01
Schriftenreihe:	BMC Genomics
Schlagworte:	Selenocysteine Selenoprotein Selenium Gene family evolution Stop codon readthrough Recoding
Online-Zugang:	https://doi.org/10.1186/s12864-026-12780-1
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