Case Report: Complete response to the concurrent neoadjuvant radiation therapy and pembrolizumab in a locally recurrent, chemotherapy-refractory undifferentiated pleomorphic sarcoma of bone

Undifferentiated pleomorphic sarcoma of bone (UPS-B) is a rare and aggressive cancer that accounts for a small fraction of bone sarcomas. Compared to both undifferentiated pleomorphic sarcoma of soft tissue (UPS-ST) and osteosarcoma, UPS-B demonstrates lower chemosensitivity and a poorer prognosis,...

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Autori principali:	Brina A. Patel, Jason T. Smith, Sintawat Wangsiricharoen, Wei-Lien Wang, Patrick P. Lin, Ahsan Farooqi, Elise F. Nassif Haddad, Kamal Ummed, Alexander F. Mericli, David M. Adelman, John Andrew Livingston, Anthony P. Conley
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-02-01
Serie:	Frontiers in Oncology
Soggetti:	bone sarcoma chemotherapy immunotherapy sarcoma undifferentiated pleomorphic sarcoma
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1645629/full
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