Studying the dynamics of the drug processing of pyrazinamide in Mycobacterium tuberculosis.
Pyrazinamide (PZA) is a key drug in the treatment of Mycobacterium tuberculosis. Although not completely understood yet, the bactericidal mechanism of PZA starts with its diffusion into the cell and subsequent conversion into pyrazinoic acid (POA) after the hydrolysis of ammonia group. This leads to...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2024-01-01
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| Colecção: | PLoS ONE |
| Acesso em linha: | https://doi.org/10.1371/journal.pone.0309352 |
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