Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells

Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in patients. Behaviorally, this manifests as memory loss and...

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Hlavní autoři:	Allie N. Greene, Lois G. Parks, Matia B. Solomon, Lisa M. Privette Vinnedge
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-11-01
Edice:	Frontiers in Molecular Neuroscience
Témata:	tau neurite formation DEK dementia—Alzheimer disease tau phosphorylation
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnmol.2020.594319/full
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