Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50’s ATPase activities and homologous recombination

Recent studies have shown that, in human cancer cells, the tetrameric Shieldin complex (comprising REV7, SHLD1, SHLD2, and SHLD3) facilitates non-homologous end-joining (NHEJ) while blocking homologous recombination (HR). Surprisingly, several eukaryotic species lack SHLD1, SHLD2, and SHLD3 ortholog...

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Bibliografische Detailangaben

Hauptverfasser:	Sugith Badugu, Kshitiza Mohan Dhyani, Manoj Thakur, Kalappa Muniyappa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2024-12-01
Schriftenreihe:	eLife
Schlagworte:	homologous recombination non-homologous end-joining Rev7
Online-Zugang:	https://elifesciences.org/articles/96933
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