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KANK2 at focal adhesions regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

Abstract Background Integrins form focal adhesions (FAs) at the cell edge and fibrillar adhesions (FBs) located centrally. Talin1 is essential to FAs, while talin2 is found in FAs and FBs. KANK (kidney ankyrin repeat-containing) family proteins regulate adhesion dynamics and are recruited to adhesio...

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Principais autores: Nikolina Stojanović, Anja Rac, Marija Lončarić, Ana Tadijan, Mladen Paradžik, Marta Acman, Jonathan D. Humphries, Martin J. Humphries, Andreja Ambriović-Ristov
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-03-01
coleção:Cell Communication and Signaling
Assuntos:
Focal Adhesion
Fibrillar Adhesion
Talin1
Talin2
KANK2
Migration
Acesso em linha:https://doi.org/10.1186/s12964-026-02771-w
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