Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation

Abstract Opioid receptors (ORs) are critical for endogenous and synthetic analgesics. OR homodimerization is considered important for their pharmacological diversity, but whether they form homodimers remains controversial. Here, we establish that the three classical ORs, μ-, κ-, and δ-ORs (MOR, KOR,...

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Detalhes bibliográficos

Principais autores:	Peng Zhou, Taka A. Tsunoyama, Rinshi S. Kasai, Koichiro M. Hirosawa, Ziya Kalay, Amine Aladag, Takahiro K. Fujiwara, Tatsushi Yokoyama, Masayuki Sakamoto, Ryoji Kise, Masataka Yanagawa, Asuka Inoue, Simone Pigolotti, Akihiro Kusumi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-64694-3
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