Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity

Abstract Mouse oocytes exhibit a unique chromatin landscape characterized by broad H3K27ac and H3K27me3 domains, demarcating euchromatin and facultative heterochromatin, respectively. However, the mechanisms underlying this non-canonical landscape remain elusive. Here we report BAP1, a core componen...

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Detalhes bibliográficos

Principais autores:	Jinwen Kang, Peiyao Liu, Shoko Ichimura, Lauryn Cook, Mengwen Hu, Satoshi H. Namekawa, Zhiyuan Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-70845-x
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