Hydrostatic pressure regulates glutamine metabolism to promote bladder fibroblast activation via the Piezo1/YAP1/GLS1 axis

Abstract Background Bladder outlet obstruction (BOO), initiated by abnormal mechanical stress, leads to progressive bladder fibrosis and functional decompensation. Abnormal mechanical stress plays a key role in the pathogenesis of various diseases, including fibrosis. However, the mechanisms through...

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Autores principales:	Kang Li, Pengyu Wei, Zhipeng Li, Wenbo Kuang, Mengyang Zhang, Changcheng Luo, Kai Cui, Dongxu Lin, Zhong Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-02-01
Colección:	Journal of Translational Medicine
Materias:	Bladder outlet obstruction Fibrosis Hydrostatic pressure Piezo1 YAP1 GLS1
Acceso en línea:	https://doi.org/10.1186/s12967-026-07855-2
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