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Epimutations in migraine and in medication overuse headache: a longitudinal study after acute medication withdrawal

Abstract Background Headache disorders are among the leading causes of neurological disability worldwide, affecting over half of the global population. Recent data indicate that headache prevalence among young people increased by 23.7% between 1990 and 2021. Migraine, a highly disabling primary head...

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Principais autores: Francesca Ferraresi, Valentina Favoni, Davide Mascarella, Chiara Pirazzini, Katarzyna Malgorzata Kwiatkowska, Francesco Ravaioli, Maria Giulia Bacalini, Daniele Dall’olio, Gastone Castellani, Claudia Sala, Giulia Pierangeli, Pietro Cortelli, Davide Gentilini, Luciano Calzari, Rossana Terlizzi, Paolo Garagnani, Sabina Cevoli
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:The Journal of Headache and Pain
Fag:
Headache
Migraine
Medication overuse
DNA methylation
Stochastic epigenetic mutations
Online adgang:https://doi.org/10.1186/s10194-026-02343-w
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