Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2

Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of 7 contiguous paternally expressed genes. Mouse models with inactivation of all PWS genes are lethal. KO mouse models for each candidate gene have been generated, but they lack the functional interactions between PWS genes. He...

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Detalhes bibliográficos

Principais autores:	Pierre-Yves Barelle, Alicia Sicardi, Fabienne Schaller, Julie Buron, Denis Becquet, Felix Omnes, Françoise Watrin, Marie-Sophie Alifrangis, Catarina Santos, Clément Menuet, Anne-Marie François-Bellan, Emilie Caron, Jessica Klucznik, Vincent Prevot, Sebastien G. Bouret, Françoise Muscatelli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2025-04-01
coleção:	JCI Insight
Assuntos:	Genetics Neuroscience
Acesso em linha:	https://doi.org/10.1172/jci.insight.185159
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