Study of the effect of anxiolytic GML-1 on the activity of cytochrome CYP2C9 and CYP1A2 isoforms

Resume. Effects of GML-1 compound on activity of isoforms CYP2C9 and CYP1A2 of cytochrome P450 using marker drugs losartane and caffeine in experiments on rats were studied. GML-1 in a dose 10 mg/kg of 10 times higher than the maximum effective anxiolytic dose 1 mg / kg (intraperitoneal administrati...

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Detalhes bibliográficos

Principais autores:	O. G. Gribakina, R. V. Shevchenko, P. O. Bochkov, A. A. Novitskiy, A. A. Litvin, G. B. Kolyvanov, V. P. Zherdev
Formato:	Artigo
Idioma:	Russo
Publicado em:	LLC “Publisher OKI” 2019-02-01
coleção:	Фармакокинетика и Фармакодинамика
Assuntos:	гмл-1 cyp2c9 cyp1a2 лозартан кофеин метаболическое отношение межлекарственное взаимодействие gml-1 losartane caffeine metabolic ratio drug-drug interaction
Acesso em linha:	https://www.pharmacokinetica.ru/jour/article/view/92
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