Prediction of hot spots in protein–DNA binding interfaces based on supervised isometric feature mapping and extreme gradient boosting

Abstract Background Identification of hot spots in protein-DNA interfaces provides crucial information for the research on protein-DNA interaction and drug design. As experimental methods for determining hot spots are time-consuming, labor-intensive and expensive, there is a need for developing reli...

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Principais autores:	Ke Li, Sijia Zhang, Di Yan, Yannan Bin, Junfeng Xia
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2020-09-01
Serija:	BMC Bioinformatics
Teme:	Protein–DNA complexes Hot spot Supervised isometric feature mapping Extreme gradient boosting
Online dostop:	http://link.springer.com/article/10.1186/s12859-020-03683-3
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