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Brassinin Enhances Apoptosis in Hepatic Carcinoma by Inducing Reactive Oxygen Species Production and Suppressing the JAK2/STAT3 Pathway

Plants from the family Brassicaceae produce brassinin (BSN), which is an essential indole phytoalexin. BSN can kill certain types of cancer cells. Using hepatocarcinoma (HCC) cells, we examined the molecular mechanisms of BSN. We found that HCC cell growth was suppressed and apoptosis was induced by...

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Hlavní autoři: Peramaiyan Rajendran, Hany Elsawy, Manal Alfwuaires, Azza Sedky
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2022-05-01
Edice:Applied Sciences
Témata:
hepatocellular carcinoma
brassinin
STAT3
transcription factors
apoptosis
ROS
On-line přístup:https://www.mdpi.com/2076-3417/12/9/4733
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