Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation

Abstract Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear tumour staining (MMR protein deficient). Four colonic adenocarcinomas and a gastric adenocarcinoma with associ...

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Автори:	Aoife J McCarthy, Jose‐Mario Capo‐Chichi, Tara Spence, Sylvie Grenier, Tracy Stockley, Suzanne Kamel‐Reid, Stefano Serra, Peter Sabatini, Runjan Chetty
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wiley 2019-04-01
Серія:	The Journal of Pathology: Clinical Research
Предмети:	adenocarcinoma colorectal gastric mismatch repair proteins immunohistochemistry mismatch repair genes
Онлайн доступ:	https://doi.org/10.1002/cjp2.120
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