Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer

Abstract Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importance of rapid therapy success assessment, which could be achieved b...

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Autores principales:	Christian Grätz, Prashant Changoer, Dapi Menglin Chiang, Johannes Kersting, Martin Jaeger, Romana Netea-Maier, Susanne I. Wudy, Christina Ludwig, Markus List, Benedikt Kirchner, Marlene Reithmair, Michael W. Pfaffl
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-09-01
Colección:	Scientific Reports
Materias:	Biomarker Anaplastic thyroid cancer Extracellular vesicles Liquid biopsy Drug repurposing Transcriptomics
Acceso en línea:	https://doi.org/10.1038/s41598-025-18319-w
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