Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant <italic toggle="yes">Klebsiella pneumoniae</italic> and <italic toggle="yes">Enterobacter cloacae</italic>

ABSTRACT Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM permeability especially in K. pneumoniae...

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Detalhes bibliográficos

Principais autores:	Tae Hwan Kim, Xun Tao, Bartolome Moya, Yuanyuan Jiao, Kari B. Basso, Jieqiang Zhou, Yinzhi Lang, Dhruvitkumar S. Sutaria, Alexandre P. Zavascki, Afonso L. Barth, Stephanie M. Reeve, Herbert P. Schweizer, Deanna Deveson Lucas, John D. Boyce, Robert A. Bonomo, Richard E. Lee, Beom Soo Shin, Arnold Louie, George L. Drusano, Jürgen B. Bulitta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2020-02-01
coleção:	mBio
Assuntos:	Enterobacter cloacae Klebsiella pneumoniae LC-MS/MS beta-lactams carbapenem resistance carbapenems
Acesso em linha:	https://journals.asm.org/doi/10.1128/mBio.03189-19
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