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MTX pathway gene variants, erythrocyte methotrexate polyglutamates, and treatment outcomes in rheumatoid arthritis

Rheumatoid arthritis (RA) exhibits significant inter-patient variability in response to and toxicity from methotrexate (MTX). The clinical utility of erythrocyte methotrexate polyglutamates (MTXPGs) and MTX-pathway pharmacogenetics remains uncertain. This study investigates the relationships betwee...

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Principais autores: Peihong Wang, Cuilv Liang, Limei Lin, Jieli Lan, Yin Zhang, Weiping Xie
Format: Artigo
Sprog:Inglês
Udgivet: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2026-01-01
Serier:Biomolecules & Biomedicine
Fag:
Rheumatoid arthritis
methotrexate
genetic polymorphisms
methotrexate polyglutamate
Online adgang:https://www.bjbms.org/ojs/index.php/bjbms/article/view/13544
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