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T-cell engagers in cancer immunotherapy: mechanisms, challenges, and future perspectives

T-cell engagers (TCEs) are a rapidly evolving class of cancer immunotherapies that redirect cytotoxic T cells to tumor-associated antigens independently of MHC presentation. This review outlines the development, structural formats, and therapeutic potential of various TCE platforms, including bispec...

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Principais autores: Kaaviyaa Muthughavi, Manoj Khokhar, Hem Chandra Jha, Rajan Kumar Pandey
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Immunology
Fag:
bispecific antibodies
cancer immunotherapy
CAR-T-cell
T-cell engagers
tumor microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1755512/full
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