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Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer...

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Principais autores: Yating Sun, Yarong Zhao, Xiuting Zhao, Robert J. Lee, Lesheng Teng, Chenguang Zhou
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-10-01
Serier:Molecules
Fag:
oligonucleotide
siRNA
miRNA
antisense
nanocarriers
Online adgang:https://www.mdpi.com/1420-3049/22/10/1724
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