Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare skin cancer caused by Merkel cell polyomavirus (MCPyV) infection and/or ultraviolet radiation–induced somatic mutations. The presence of tumor-infiltrating lymphocytes is evidence that an active immune response to MCPyV and tumor-associated neoantigens occurs in...

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Autores principales:	Dirk Schadendorf, Paul Nghiem, Shailender Bhatia, Axel Hauschild, Philippe Saiag, Lisa Mahnke, Subramanian Hariharan, Howard L. Kaufman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2017-10-01
Colección:	OncoImmunology
Materias:	avelumab checkpoint inhibition immune evasion merkel cell carcinoma pd-1 pd-l1 pembrolizumab
Acceso en línea:	http://dx.doi.org/10.1080/2162402X.2017.1338237
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