Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs.

Oseltamivir is a widely used influenza virus neuraminidase (NA) inhibitor that prevents the release of new virus particles from host cells. However, oseltamivir-resistant strains have emerged, but effective drugs against them have not yet been developed. Elucidating the binding mechanisms between NA...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jiaye Tao, Heping Wang, Wenjian Wang, Na Mi, Wei Zhang, Qiujia Wen, Jiajing Ouyang, Xinyun Liang, Min Chen, Wentao Guo, Guoming Li, Jun Liu, Hanning Zhao, Xin Wang, Xuemeng Li, Shengjun Feng, Xinguang Liu, Zhiwei He, Zuguo Zhao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2022-07-01
Schriftenreihe:	PLoS Computational Biology
Online-Zugang:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010343&type=printable
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!