Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing—Using Rifampicin as an Example

Rifampicin exhibits complexities in its pharmacokinetics (PK), including high inter-occasion variability (IOV), which is challenging for dose individualization. Model-informed precision dosing (MIPD) can be used to optimize individual doses. In this simulation-based study we investigated the magnitu...

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Hauptverfasser:	Lina Keutzer, Ulrika S. H. Simonsson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-05-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	model-informed precision dosing inter-occasion variability tuberculosis rifampicin Bayesian forecasting precision dosing
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fphar.2020.00794/full
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