Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

Abstract Fibrosis induced immune exclusion is a hepatocellular carcinoma (HCC) hallmark, underscoring the key role of cancer‐associated fibroblasts (CAFs) in immune regulation. Through HCC spatial multi‐omics data and integrating pan‐cancer scRNA‐seq profiles of CAFs under immune checkpoint blockade...

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Bibliografische Detailangaben

Hauptverfasser:	Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-04-01
Schriftenreihe:	iMeta
Schlagworte:	cancer associated fibroblast hepatocellular carcinoma immunotherapy NOTCH3 spatial omics
Online-Zugang:	https://doi.org/10.1002/imt2.70117
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