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Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

Read-across has matured from an expert-driven extrapolation based largely on structural analogy into a rigorously documented, mechanistically informed cornerstone of next-generation risk assessment. Three pivotal frameworks are compared that now shape its regulatory use: the European Food Safety Aut...

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Главные авторы: Thomas Hartung, Costanza Rovida
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2025-12-01
Серии:Frontiers in Toxicology
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Online-ссылка:https://www.frontiersin.org/articles/10.3389/ftox.2025.1690491/full
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