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Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells

Abstract Background The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission inducing protein required for membrane trafficking and Golgi complex partitioning during mitosis, hence for mitotic entry....

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Principais autores: Angela Filograna, Stefano De Tito, Matteo Lo Monte, Rosario Oliva, Francesca Bruzzese, Maria Serena Roca, Antonella Zannetti, Adelaide Greco, Daniela Spano, Inmaculada Ayala, Assunta Liberti, Luigi Petraccone, Nina Dathan, Giuliana Catara, Laura Schembri, Antonino Colanzi, Alfredo Budillon, Andrea Rosario Beccari, Pompea Del Vecchio, Alberto Luini, Daniela Corda, Carmen Valente
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
C-terminal Binding Protein (CtBP)
Rossmann fold
Benzenesulfonamide
CtBP inhibitor
Melanoma
Online adgang:https://doi.org/10.1186/s13046-024-03044-5
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