Ext1-targeted gene therapy ameliorates tauopathy by inhibiting heparan sulfate-dependent tau propagation

The propagation of pathological tau protein in neuronal cells is a critical driver of neurodegeneration in tauopathies, including Alzheimer's disease. Heparan sulfate (HS) critically regulates pathological tau seeding and cellular uptake processes closely linked to the development of tau pathology i...

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Detalhes bibliográficos

Principais autores:	Rongyao Huang, Xiaoxun Ye, Jiayi Liu, Chunyan Yang, Xiaoya Meng, Tingting Dou, Xiaoqing Zhuang, Jinghan Yang, Naizhen Zheng, Yang Zhao, Zhongan Wang, Qin Wang, Jin Hu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-08-01
coleção:	Pharmacological Research
Assuntos:	Tauopathies Heparan sulfate Ext1 Adeno-associated viral vector Tau propagation Antisense oligonucleotide
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661826001805
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