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Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight

Abstract Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T a...

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Principais autores: Michaela Gregorova, Marianna Santopaolo, Lucy C. Garner, Rahma F. Hayati, Divya Diamond, Narayan Ramamurthy, Vi Thuy Tran, Nguyet Minh Nguyen, Kate J. Heesom, Vuong Lam Nguyen, Eben Jones, Mike Nsubuga, Curtis Luscombe, Hoa Thi My Vo, Chanh Quang Ho, Chau Thi Xuan Nguyen, Tam Thi Hoai Dong, Duyen Thi Le Huynh, Tam Thi Cao, Andrew D. Davidson, Paul Klenerman, Sophie Yacoub, Laura Rivino
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-07-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-025-60941-9
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