Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. Methods: We employed a combination of neuroanatomical, genetic, and beh...

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Egile Nagusiak:	Alessia Costa, Minrong Ai, Nicolas Nunn, Isabella Culotta, Jenna Hunter, Mehdi Boutagouga Boudjadja, Lourdes Valencia-Torres, Gabriella Aviello, David J. Hodson, Brandy M. Snider, Tamer Coskun, Paul J. Emmerson, Simon M. Luckman, Giuseppe D'Agostino
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2022-01-01
Saila:	Molecular Metabolism
Gaiak:	Brain Appetite Nausea Glucagon-like peptide-1 Glucose-dependent insulinotropic polypeptide Cholecystokinin
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2212877821002659
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