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Epigenetic modulations in cancer: predictive biomarkers and potential targets for overcoming the resistance to topoisomerase I inhibitors

AbstractIntroduction Altered epigenetic map is frequently observed in cancer and recent investigations have demonstrated a pertinent role of epigenetic modifications in the response to many anticancer drugs including the DNA damaging agents. Topoisomerase I (Top I) is a well-known nuclear enzyme tha...

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Autors principals: Moustafa M. Madkour, Wafaa S. Ramadan, Ekram Saleh, Raafat El-Awady
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2023-12-01
Col·lecció:Annals of Medicine
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Accés en línia:https://www.tandfonline.com/doi/10.1080/07853890.2023.2203946
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