Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2...

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Autores principales:	Petra Mooij, Juan García-Arriaza, Patricia Pérez, Adrian Lázaro-Frías, Babs E. Verstrepen, Kinga P. Böszörményi, Daniella Mortier, Zahra Fagrouch, Gwendoline Kiemenyi-Kayere, Henk Niphuis, Roja Fidel Acar, Lisette Meijer, Marieke A. Stammes, Ivanela Kondova, Ernst J. Verschoor, Corine H. GeurtsvanKessel, Erwin de Bruin, Reina S. Sikkema, Joanna Luczkowiak, Rafael Delgado, Dolores Montenegro, Eugenia Puentes, Esteban Rodríguez, Willy M. J. M. Bogers, Gerrit Koopman, Mariano Esteban
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2022-03-01
Colección:	Frontiers in Immunology
Materias:	SARS-CoV-2 COVID-19 spike MVA vaccine rhesus macaques safety
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full
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